It is used in the prophylaxis and treatment of vitamin B6 deficiency and drug induced causes (e.g. Isoniazid, hydralazine, oral contraceptives) or inborn errors of metabolism. It is also used for premenstrual syndrome (PMS) and other menstruation problems, morning sickness (nausea and vomiting) in e...
Tablets should be taken with or without food in adult dose, in the following conditions.
General deficiency: Dose up to 150 mg daily
Prophylaxis of isoniazid induced peripheral neuritis: 10 mg or up to 50 mg daily.
Treatment of sideroblastic anaemia: Dose up to 400 mg daily.
Treatment of certain metabolic disorders: Dose up to 400 mg daily.
Treatment of peripheral neuritis: 100 mg to 200 mg daily.
Each tablet contains:
Pyridoxine Hydrochloride B.P ... 40 mg.
Pyridoxine, vitamin B6, is a part of the vitamin B group of essential nutrients. Its active form, pyridoxal 5' phosphate, serve as a coenzyme in some I 00 enzyme reactions in amino acid, glucose and lipid metabolism. Chemically, it is (5-hydroxy-6-methylpyridine-3, 4-diyl) dimethanol hydrochloride. ...
Vitamin B6, in the form of pyridoxal 5' phosphate, was found to protect vascular endothelial cells in culture from injury by activated platelets. Endothelial injury and dysfunction are critical initiating events in the pathogenesis of atherosclerosis. Vitamin B6 deficiency results in altered lymphoc...
Pyridoxine is absorbed by passive diffusion in the jejunum and to a lesser extent in the ileum and is converted to active forms of pyridoxal phosphate and pyridoxamine phosphate. They are primarily stored in the liver; lesser amount in muscle and brain. They have no protein bound. They are metaboliz...
Contraindicated in patients who have hypersensitivity to pyridoxine or any component of the medication.
Pregnancy and lactation (excreted in breast milk, may inhibit lactation)
Children (safety and efficiency not established in doses exceeding nutritional requirement)
Overdosage can cause ataxia and sensory neuropathy.
When taken in large doses for a long time, patient may experience mild side effects like headache, nausea, drowsiness, numbness (tingling of arms and legs). A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allerg...
Concomitant use of vitamin B6 and amiodarone may enhance amiodarone-induced photosensitivity reactions. Doses of vitamin B6 greater than 5 - IO mg/day should be avoided by those taking amiodarone.
Concomitant use ofLevodopa and vitamin B6 in daily dose of 5 mg or more may reverse the therapeutic effects of levodopa. Vitamin B6 does not reverse the therapeutic effects oflevodopa iflevodopa is taken concurrently with the levodopa decarboxylase inhibitor, carbidopa. Levodopa is typically adminis...
High dose of vitamin B6 may lower plasma levels of phenobarbital and phenytoin.
Store below 30°C in cool, dry place. Protect from light and moisture. Keep out of reach and sight of children.
Presentation
20 x 10's Blisters, 100's Bottle.