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PARASHIN - Cold is used in the symptomatic treatment of nasal congestion, nasal catarrh, sneezing, headache, body aches and fever associated with common cold, flu and other acute respiratory tract infections.
Adults: 1 to 2 caplets to be taken 3 to 4 times a day or as recommended by Healthcare Professionals. Maximum Dose: Do not take more than 8 caplets within 24 hours unless it is directed by the physician. Should be taken as a whole caplet and do not break the caplet in half.
Each film-coated caplet contains:
Paracetamol B.P ................................ 500 mg
Chlorpheniramine Maleate B.P ............ 2 mg
Phenylephrine Hydrochloride B.P ........ 5 mg.
Paracetamol is N-acetyl para-amino phenol derivatives. It has analgesic, antipyretic and weak anti-inflammatory activity. Chemical formula is C8H9NO2 and its molecular weight is 151.2. Chlorpheniramine Maleate is a H1 -receptor antagonist, antihistamine. Chemically, it is (3RS)-3-(4-Chlorophen...
Paracetamol, also known as acetaminophen, is an inhibitor of the enzyme cyclo-oxygenase and inhibits the synthesis of prostaglandins in the central nervous system and peripherally blocks pain impulse generation; produces antipyresis from inhibition of hypothalamic heat-regulating center. There...
Paracetamol is readily absorbed from the GI tract. Peak plasma concentration occurs at 10-60 minutes after oral dose. It is distributed into most body tissues. It crosses the placenta and present in breast milk. Plasma protein binding is negligible at usual therapeutic concentration but increase wit...
Chlorpheniramine is absorbed selectively and slowly from the gastrointestinal tract, peak plasma concentrations occurring about 2.5 to 6 hours after administration by mouth. It appears to undergo first pass metabolism, about 70%is bound to plasma proteins. It is metabolized primarily hepatic vi...
Phenylephrine Hydrochloride is readily and completely absorbed from the gastrointestinal tract. Following oral administration, peak plasma concentrations are achieved in 1-2 hours. The mean plasma half-life is in the range 2-3 hours. The volume of distribution is large (200 to 500 litres). Penetrati...
It is contraindicated in patients who have hypersensitivity to paracetamol, chlorpheniramine and phenylephrine; patients with severe hypertension or severe coronary artery disease or those receiving monoamine oxidase inhibitors (MAOI); and newborn and premature infants.
PARASHIN - Cold should be used with caution in patients with a history of asthma, narrow-angle glaucoma, stenosing peptic ulcer, gastrointestinal obstruction or urinary bladder neck obstruction, hypertension, heart disease, uncontrolled diabetes or hyperthyroidism. Anti-histamine can cause reduced m...
The most common adverse effects are increased blood pressure, increased heart rate, dizziness, drowsiness, nausea, vomiting, dry mouth, loss of appetite, indigestion, abdominal pain, diarrhea, urinary retention, palpitation, tremor, muscular weakness and ringing sensation in ears.
MAOI : Concurrent administration may result in unpredictable increase in blood pressure by increased receptor activity.
Antihypertensives: Sympathomimetics may reduce the effect of antihypertensive drugs.
Alcohol: Increased risk of liver damage.
Store below 30ºC in cool, dry place. Protect from light and moisture. Keep out of reach and sight of children.
10x10’s Blisters.