Ofloxacin is used in the treatment of a wide range of infections including complicated urinary tract infections, lower respiratory tract infections, septicemia, skin and soft tissue infections, gonorrhoea, gastro-enteritis, Legionnaires' disease, pneumonia, bladder infection, and Traveler's diarrhea...
Adult recommended dose of Ofloxacin is as follow:
Urinary Tract Infections: 200 - 400 mg daily, preferably taken in the morning; increased if necessary, to 400 mg twice daily in upper urinary tract infections
Acute or Chronic Prostatitis: 200 mg twice daily for 28 days
Lower Respiratory Tract Infections: 400 mg twice daily, dose preferably taken in the morning, then increased if necessary, to 400 mg twice daily
Skin and Soft Tissue Infections: 400 mg twice daily
Uncomplicated Gonorrhoea: 400 mg once daily as a single dose Uncomplicated Genital Clamydial Infections (Non-gonococcal Urethritis): 400 mg daily for 7 days; dose may be taken as a single daily dose or divided dose
Pelvic inflammatory Disease: 400 mg twice daily for 14 days
Each film-coated caplet contains:
Ofloxacin USP ... 200 mg.
Ofloxacin is quinolone antibiotics. It is useful for the treatment of a number of bacterial infections. Its chemical formula is C18H20FN304 and molecular weight is 361.37.
Ofloxacin is a broad-spectrum antibiotic that is active against both Gram-positive and Gram-negative bacteria. It is a DNA gyrase inhibitor. DNA gyrase is an essential bacterial enzyme that maintains the superhelical structure of DNA. DNA gyrase is required for DNA replication and transcription, DNA...
Ofloxacin is a racemic mixture, which consists of 50% levofloxacin (the biologically active component) and 50% of its mirror image or enantiomer dextrofloxacin. It is extremely active against Gram negative organisms and less active against Gram positive organism. Organisms susceptible to ofloxacin i...
Gram positive - Enterococcus faecalis, Staphylococcus epidermidis including methicillin resistant strains, Staphylococcus saprophyticus, Streptococcus agalactiae; Gram negative - Aeinetobacter spp, Aeromonas hydrophila, Camphylobacter jejuni, Citrobacter freundii, Enterobacter cloacae, Haemophilus p...
Anaerobes - Bacteroides fragilis, Clostridium spp, Gardnerella vaginalis, Peptostreptococci;
Other organisms - Legionella pneumophila, Mycoplasma pneumoniae, Mycobacterium tuberculosis, M. leprae, Ureaplasma urealyticum.
Ofloxacin is well absorbed when given orally. Time to peak plasma concentration: 1-2 hr. The plasma protein binding of ofloxacin is about 31% and the plasma elimination half-life is about 6-8 hrs. Ofloxacin is widely distributed in the tissues and body fluids viz, lungs, skin, blister fluid, cervix,...
Hypersensitivity to ofloxacin or other members of the quinolone group; or any component of the medication.
It is used with caution in patients with epilepsy or other CNS disease which could predipose seizures and then use with caution in patients with renal impairment, failure to respond to an ophthamic antibiotic after 2-3 days may indicate in the presence of resistant organism or another causative agen...
It has common side effects including vomiting, diarrhoea, headache and rash. Other serious adverse effects include tendon rupture, numbness due to nerve damage, seizure and psychosis. The severe or irreversible side effects include sinus tachycardia, hallucinations, Stevens Johnson Syndrome. Ofloxac...
Azlocillin, cimetidine and probenecid may increase serum levels. Forcarnet and NSAIDs have been associated with the increased risk of seizures with some quinolones. Serum levels of some quinolones are increased by loop diuretic administration. The hypoprothrombinemic effects of warfarin is enhanced ...
Ofloxacin can chelate alkaline earth and transition metal cations. Administration of quinolones with antacids containing calcium, magnesium, or aluminum, with sucralfate, with divalent or trivalent cations such as iron, or with multivitamins containing zinc may substantially interfere with the absor...
Store below 30°C in cool, dry place. Protect from light and moisture. Keep out of reach and sight of children.
10 x 10's Blisters.