Dicloshin
Diclofenac
Indication
It is used in the treatment of Rheumatoid arthritis, osteoarthritis, low back pain, ankylosing spondylitis, gout, acute musculoskeletal disorders, periarthritis (frozen shoulders), tendonitis, tenosynovitis, bursitis, sprains and dislocations. It is also used in painful post-traumatic and post-opera...
Dosage and Administration
For the relief of osteoarthritis, the recommended dosage is 100-150 mg/day in divided doses
For the relief of rheumatoid arthritis, the recommended dosage is 150-200 mg/day in divided doses
For the relief of ankylosing spondylitis, the recommended dosage is 100-150 mg/day in divided doses
Adults: 100 - 150 mg in 2 - 3 divided doses
Maintenance therapy: 50 – 100 mg in divided doses These tablets are not suitable for children aged under 12. Diclofenac should be taken with food to prevent from upset stomach. Do not take more or use it for a longer duration than recommended by the doctor.
Composition
Each enteric-coated tablet contains:
Diclofenac Sodium B.P ... 50 mg.
Description
Diclofenac Sodium is a phenylacetic acid derivative and non-steroidal anti-inflammatory drugs (NSAIDs) which has analgesic, antipyretic and anti-inflammatory activity. Chemically, it is sodium [2-[(2, 6-dichlorophenyl) amino] phenyl] acetate. Its chemical formula is C14H10Cl2NNaO2 and molecular weig...
Clinical Pharmacology
Diclofenac sodium is a non-steroidal agent with marked analgesic/anti-inflammatory properties. It is an inhibitor of prostaglandin synthetase, (cyclo-oxygenase). Diclofenac sodium in vitro does not suppress proteoglycan biosynthesis in cartilage at concentrations equivalent to the concentrations rea...
Pharmacokinetics
Diclofenac is completely absorbed from the GI tract but likely undergoes significant first pass metabolism with only 60% of the drug reaching systemic circulation unchanged. Maximum plasma levels are reached within 1-16 hours depending on how long passage through the stomach takes and are reached on...
Contraindication
It is contraindicated in patients who have known hyper-sensitivity to diclofenac and diclofenac-containing products and should not be given to patients who have experienced asthma, urticarial or other allergic-type reaction after taking aspirin or other NSAIDS. Severe, rarely fatal, anaphylactic-lik...
Warning and Precaution
Diclofenac Sodium should not be given to patients who is suffering from asthma, hay fever, nasal polyps, chronic obstructive pulmonary diseases (COPD) or patients with gastro-intestinal problems such as stomach ulcers, bleeding or black stools and heart disease, high blood pressure, liver disease an...
Adverse Effect
Common side effects are stomach pain, heartburn, nausea, vomiting, diarrhea, indigestion, wind, loss of appetite, headache, dizziness, vertigo, skin rash or spots and raised levels of liver enzymes in the blood. Heart palpitations can sometimes occur but rare.
Drug Interaction
Concomitant administration of diclofenac and other anti-inflammatory medicines such as aspirin or ibuprofen. Caution should be used when NASIDs are administered concomitantly with antibiotics, such as ciprofloxacin, levofloxacin, moxifloxacin, nalidixic acid, norfloxacin or ofloxacin. Diclofenac sod...
Storage
Store below 30 C in cool and dry place. Protect from light and moisture. Keep out of reach and sight of children.
Presentation
10 x 10’s Blisters