It is indicated in Type 2 diabetes mellitus as monotherapy if metformin inappropriate and in combination with insulin or other antidiabetic drugs. It is indicated as an adjunct to diet and exercise to improve glycemic control in adults with Type 2 diabetes mellitus.
The recommended starting dose is 5mg once a day, taken in the morning, with or without food. The maximum dose is 10mg once a day. Assess renal function before initiating Dapashin.
Each film-coated tablet contains:
Dapagliflozin Propanediol monohydrate equivalent to Dapagliflozin ... 5 mg / 10 mg.
Dapagliflozin is an antidiabetics, sodium-glucose cotransporter 2 (SGLT2) inhibitor. It is described chemically a D-glucitol, 1, 5-anhydro-1-C-[4-chloro-3-[(4-ethoxyphenyl) methyl] phenyl]-, (1S)-, compounded with (2S)-1, 2-propanediol, hydrate (1:1:1). Chemical formula is C21H25ClO6 C3H8O2 H2O...
It helps lower blood glucose levels by helping the body to filter more excess glucose out of the blood. Sodium-glucose cotransporter 2 (SGLT2), expressed in the proximal renal tubules, is responsible for the majority of the reabsorption of filtered glucose from the tubular lumen. Dapagliflozin is an...
Dapagliflozin is rapidly and well absorbed after oral administration. The absolute oral bioavailability of dapagliflozin following the administration is 78%. It can be administered with or without food. Dapagliflozin is approximately 91% protein bound. Protein binding was not altered in various dise...
It is contraindicated in patients who have known hypersensitivity to dapagliflozin or dapagliflozin containing products and should not be given to patients who have experienced severe renal impairment (eGFR < 30 mL/min/ 1.73 m2). It is not indicated for use in patients with type 1 diabetes mellitus ...
It should be given with care to patients with renal impairment, hepatic impairment, diabetic ketoacidosis, necrotizing fasciitis of the perineum, urinary tract infections, cardiac failure, chronic kidney disease and lower limb amputations. It should not be administered to patients at risk for volume...
The common side effects are diabetic ketoacidosis (discontinue immediately), back pain, balanoposthitis, dizziness, dyslipidaemia, hypoglycaemia( in combination with insulin or sulfonylurea), rash and urinary disorders.
Hypoglycemic Agents: May enhance the adverse/toxic effect of other hypoglycemic agents.Hypotensive Agents: May enhance the adverse/toxic effect of other hypotensive agents. Loop Diuretics: May diminish the hypoglycemic effect of hypoglycemic agents. MAO Inhibitors: May enhance the hypoglycemic effec...
Store below 30℃ in cool and dry place. Protect from light and moisture. Keep out of reach and sight of children.
3 x 10’s Blisters