Aspirin 300 mg

Indication

Aspirin is used for the relief of mild to moderate pain; used in acute and chronic inflammatory disorders: used in treatment of minor febrile conditions and used for reduction of temperature.

Dosage and Administration

Usual dose is 300 mg to 900 mg (1- 3 tablets) every 4 - 6 hours according to clinical needs, up to maximum of 4 g daily or as recommended by the physician.

Composition

Each tablet contains:

Aspirin BP ... 300 mg.

Description

Aspirin is a non-selective cyclo-oxygenase inhibitor. Aspirin, 2-(Acetyloxy) benzoic acid, is a weak acid (pKa 3.5). Its structural formula is C9H804 and its molecular weight is 108.2.

Clinical Pharmacology

Aspirin irreversibly inhibits acetylation cyclooxygenases, which converts arachidonic acid to cyclic endoperoxides, first step in synthesis of prostaglandins, thromboxanes and prostacyclins. Inhibition of thromboxane synthesis underlines antithrombotic effect, while inhibition of prostaglandin synth...read more

Pharmacokinetics

After oral administration, aspirin is completely and rapidly absorbed from gastrointestinal tract, in non-ionized form and bound to plasma protein. Plasma concentration declines as plasma salicylate concentration increase. Aspirin is prodrug and is rapidly hydrolyzed to acetic acid and salicylate by...read more

Contraindication

Hypersensitivity to salicylates, other NSATDs, or any component of the formulation.

Pregnancy (especially 3rd Trimester): high doses (analgesic doses) cause closure of fetal ductus arteriosus, increased risk of haemorrhage, increased duration of labour with increased blood loss.

Infant and children should avoid because of risk ofReye's syndrome.

During uricosuric therapy

Severe cardiac failure

If the patient has previous active peptic ulcer disease, aspirin can cause haemophilia.

Precaution

Use with caution in mild to moderate renal failure. Patients with sensitivity to tartrazine dyes, nasal polyps and asthma may have and increase risk of salicylate sensitivity. Surgical patients should avoid aspirin if possible, for 1 - 2 weeks prior to surgery, to reduce the risk of excessive bleedi...read more

Adverse Effects

Confusion, GI haemorrhage, GI irritation, tinnitus, skin reactions in hypersensitive patients.

Drug Interaction

Alcohol (ethanol): Alcohol should be avoided while taking aspirin. Alcohol can increase risk of stomach bleeding caused by aspirin.

Anticoagulants: Salicylates may enhance hypoprothrom­binaemic effect of warfarin and other anticoagulants and increased the risk of bleeding complication with these agents.

Uricosuric agents: The uricosuric effects of salicylates and phenylbutazone, probenecid or sulfinpyrazone are antagonistic.

Antidiabetic agents: The hypoglycaemic effect of sulfonylureas (e.g. chlorpropamide, tolbutamide) may enhanced by salicylates.

Corticosteroids: Serum salicylaste concentrations may Decrease when corticosteroids are administered conco­mitantly.

NSAIDs: Salicylates should not be used in con­ junction with other NASIDs,since it has not been estab­ lished that combination therapy is more efficacious than the individual agent alone and potential for adverse ef­ fects may be increased.

Storage

Store below 30°C in cool, dry place. Protect from moisture and light. Keep out of reach and sight of children.

Presentation

10 x l0's Blisters.